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      Are babies of vaccinated Pregnant and lactating mothers with ChAdOx1 AstraZeneca covid vaccine more risk for zinc deficiency and SCID disease.

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      research-article
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      ScienceOpen Preprints
      ScienceOpen
      Astrazeneca, vaccine, ChAdOx1, COVID-19, Corona, EDTA, Zinc, ADA, SCID
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            Abstract

            AstraZeneca's covid-19 vaccine demonstrates some concerns regarding its excipients, such as polysorbate 80, which serves as a stabilizer, and EDTA, which serves as a binding agent. 7

            ADA is a critical purine metabolic enzyme required for adequate immunological competence. The current study examines the effect of Zn2+ on the maintenance of ADA. After eliminating Zn2+, the protein's crystallographic structure has retained a high degree of order and similarity to the original one, with some alterations limited to the areas surrounding the pocket. However, the protein's stability has been dramatically reduced.

            EDTA is a highly effective zinc-chelating agent employed in the investigations of protein interactions. The potential damage of the structure and interactions of zinc-binding proteins by EDTA treatment must be considered. Excess Zn2+ has not returned C/H1 to its normal structure, highlighting the irreversible denaturation induced by the EDTA.

            Around 30% of proteins in cells form complexes with metals. Metal ions are essential not just for regulating biological functions but also for stabilizing proteins. (ADA, EC 3.5.4.4) has a molecular mass of 40 kDa and contains a firmly attached zinc ion essential for its activity. The lack of its enzymatic activity leads to malfunction B and T cells, and SCID development

            Content

            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            24 October 2021
            Affiliations
            [1 ] Department of Public Health, Tuberculosis Program, First Health Cluster, Ministry of Health, Riyadh, Saudi Arabia.
            [2 ] Department of chemistry and biochemistry, Faculty of Science, Damietta University, Egypt
            Author notes
            Article
            10.14293/S2199-1006.1.SOR-.PP3SFAE.v1
            fcfc60e3-d0f4-49b3-9bb4-d8dd7472d435

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            Funding
            NO NO

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Neonatology,Pharmacology & Pharmaceutical medicine,Infectious disease & Microbiology
            COVID-19,SCID,EDTA,Corona,Astrazeneca,ADA,ChAdOx1,vaccine,Zinc

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