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      Potential role of Zinc supplement in CVD and COVID-19 co-morbidity

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            Abstract

            As far as the comorbidity is concerned, cardiovascular diseases (CVD) appear to be accounted for the highest prevalence, severity, and fatality among COVID 19 patients. A wide array of causal links connecting CVD and COVID-19 baffle the overall prognosis as well as the efficacy of the given therapeutic interventions. At the centre of this puzzle lies ACE2 that works as a receptor for the SARS-CoV-2 and functional expression of which is also needed to minimize vasoconstriction otherwise would lead to high blood pressure. Furthermore, SARS-CoV-2 infection seems to reduce the functional expression of ACE2. Given these circumstances, it might be advisable to consider a treatment plan for COVID-19 patients with CVD in an approach that would neither aggravate the vasodeleterious arm of RAAS nor compromise the vasoprotective arm of RAAS but is effective to minimize or if possible, inhibit the viral replication. A zinc supplement to the selective treatment plan, to be decided by the clinicians depending on the cardiovascular conditions of the patients, is hereafter proposed that might greatly enhance the therapeutic outcome. Notably, ACE2 is a zinc metalloenzyme and zinc is also known to inhibit viral replication.

            Content

            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            28 October 2020
            Affiliations
            [1 ] Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh
            [2 ] Institute of National Analytical Research and Service (INARS), Bangladesh Council of Scientific and Industrial Research (BCSIR), New Elephant Road, Dhaka 1205, Bangladesh
            [3 ] Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia
            Article
            10.14293/S2199-1006.1.SOR-.PP3ZKDJ.v1
            d3391ce9-522d-4c09-9c69-b5aaa55fcccc

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            Funding
            No funding was required, the manuscript is a review article. Not applicable

            All data generated or analysed during this study are included in this published article (and its supplementary information files).
            Life sciences
            Angiotensin converting enzyme,Comorbidity,high blood pressure,vasodilation,vasoconstriction,SARS-COV-2,Zinc

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