ISOLATION CHARACTERISATION AND ANTIMICROBIAL ACTIVITY OF A BIOATIVE COMPOUND FROM ROOTS OF Urena lobata

Stigmasterol was isolated from the roots of Urena lobatausing ¹HNMR and ¹³CNMR. Stigmasterol, n-hexane, ethyl acetate and methanolic extracts were subjected to antimicrobial test using the following microbes: Methicillin Resistant Staphylococus aureus, Vancomycin Resistant enterococci, Staphylococus aureus, Escheria coli, Neisseria gonorrhea, Candida albicans, Candida krusei and Candida stellatoidea. The isolate showed the highest zone of inhibition of 31 mm followed by ethyl acetate extract(28 mm) and methanolic extract (23 mm). The MIC, MBC/MFC result showed that Staphylococus aureus, Candida kruseiand Candida stellatoideawere insensitive to both the isolate and plant extracts. The result justifies the use of roots of Urena lobatain traditional herbal medicine for the treatment of various microbial diseases like menstrual disorder

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Title: ScienceOpen Preprints

Publisher: ScienceOpen

Publication date (Electronic preprint): 9 December 2022

Affiliations

[1 ] FEDERAL UNIVERSITY OF AGRICULTURE MAKURDI - NIGERIA

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[* ]Email: emaikwupatience51@ 123456gmail.com .

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patience emaikwu https://orcid.org/0000-0001-5542-9611

Article

DOI: 10.14293/S2199-1006.1.SOR-.PPN89EX.v1

SO-VID: a6761bb4-1d16-43c9-bacd-65bcbdf1e2f5

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This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

History

Date received : 9 December 2022

References

Ben-Eledo Vivian, Kigigha Lovet, Izah Sylvester, Eledo Benjamin. Water Quality Assessment of Epie Creek in Yenagoa Metropolis, Bayelsa State, Nigeria. Archives of Current Research International. Vol. 8(2):1–24. 2017. Sciencedomain International. [Cross Ref]

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[1] Ben-Eledo Vivian, Kigigha Lovet, Izah Sylvester, Eledo Benjamin. Water Quality Assessment of Epie Creek in Yenagoa Metropolis, Bayelsa State, Nigeria. Archives of Current Research International. Vol. 8(2):1–24. 2017. Sciencedomain International. [Cross Ref]