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      The Link between Cancer, Autoimmunity and Diabetes

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      ScienceOpen Preprints
      ScienceOpen
      cancer, autoimmunity, diabetes
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            Abstract

            In cancer, corrupted neoplastic cell successfully evades the immune attack using two main strategies: avoiding the immune recognition and instigating an immunosuppressive tumor microenvironment. Cancer is able to induce immune tolerance and present itself to immune system as normal tissue. There is a defect in immune tolerance: the tolerance is wrongly induced toward cancer. In autoimmune diseases, immune system attacks normal tissue because it fails to recognize its own constituent parts as self. There is a defect in immune tolerance: the tolerance is lost toward normal tissues. In both diseases wrong information in the communication between tissue (neoplastic) cells and immune system is crucial: in cancer, neoplastic cells avoid immune attack, whilst in autoimmune diseases, immune system attacks normal cells. Diabetes mellitus type I and II are associated with an increased risk of developing different types of cancer. Pathogenesis of diabetes mellitus type I and pathogenesis of cancer overlap in genetic, environmental and immunologic factors. Diabetes mellitus type II and obesity can both induce oncogenesis.

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            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            4 October 2021
            Affiliations
            [1 ] Clinical pharmacology and toxicology, University Hospital Center, Soltanska 1, 21000 Split, Croatia
            Author notes
            Article
            10.14293/S2199-1006.1.SOR-.PPXAL5B.v1
            f3e6c3c5-5eb9-452a-b8b0-78029101e606

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .


            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Medicine
            cancer,autoimmunity,diabetes

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