Research mainly in the field of “multidrug-resistance to anticancer drugs” and especially on “mechanisms of resistance to topoisomerase I and II inhibitors, and telomerase inhibitors. From the beginning of 2008, his research interests are the response of cancer cells to chemotherapy and modulation of this response by the cellular microenvironment (protection and/or sensitization).
Teaching activities in Biochemistry, Molecular Biology and Genetics, Molecular Pathology, Tumor Progression and Therapeutic Strategies, Cellular and Tumour Microenvironment Factors Mediating Drug Resistance.
Specialties: The limitations of cancer chemotherapy have been attributed primarily to cellular mechanisms. Recent data suggest that tumour microenvironment allows tumour to escape treatment during the first exposure. Two forms have been recently described : the first is called soluble factor-mediated drug resistance (SFM-DR) and the second is called cell adhesion-mediated drug resistance (CAM-DR)