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Transposition in Mycobacteria

edited_book

Author(s): Ruth A. McAdam , Christophe Guilhot , Brigitte Gicquel

Publication date (Online): April 08 2014

Publisher: ASM Press

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Most cited references 73

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Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines.

Susan Hoiseth, B. A. D. STOCKER (1981)

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New use of BCG for recombinant vaccines.

C. K. Stover, V F de la Cruz, T. Fuerst … (1991)

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.