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      The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients.

      Diabetes Care
      Administration, Oral, Adult, Aged, Algorithms, Blood Glucose, drug effects, Body Weight, Diabetes Mellitus, Type 2, drug therapy, Drug Therapy, Combination, Female, Humans, Hypoglycemia, chemically induced, Hypoglycemic Agents, administration & dosage, adverse effects, Insulin, analogs & derivatives, Insulin, Isophane, Insulin, Long-Acting, Male, Middle Aged, Treatment Outcome

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          Abstract

          To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c). In a randomized, open-label, parallel, 24-week multicenter trial, 756 overweight men and women with inadequate glycemic control (HbA(1c) >7.5%) on one or two oral agents continued prestudy oral agents and received bedtime glargine or NPH once daily, titrated using a simple algorithm seeking a target fasting plasma glucose (FPG)

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