The role of salt for immune cell function and disease

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Summary

The immune system evolved to protect organisms from invading pathogens. A network of pro‐ and anti‐inflammatory cell types equipped with special effector molecules guarantees efficient elimination of intruders like viruses and bacteria. However, imbalances can lead to an excessive response of effector cells incurring autoimmune or allergic diseases. An interplay of genetic and environmental factors contributes to autoimmune diseases and recent studies provided evidence for an impact of dietary habits on the immune status and related disorders. Western societies underwent a change in lifestyle associated with changes in food consumption. Salt (sodium chloride) is one component prevalent in processed food frequently consumed in western countries. Here we summarize recent advances in understanding the mechanisms behind the effects of sodium chloride on immune cells like regulatory T cells (Tregs) and T helper (T _H) 17 cells and its implication as a risk factor for several diseases.

Most cited references 58

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Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Marie Ng, Tom Fleming, Margaret W. Robinson … (2015)

In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9% of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparable, up-to-date information about levels and trends is essential to quantify population health effects and to prompt decision makers to prioritise action. We estimate the global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013. We systematically identified surveys, reports, and published studies (n=1769) that included data for height and weight, both through physical measurements and self-reports. We used mixed effects linear regression to correct for bias in self-reports. We obtained data for prevalence of obesity and overweight by age, sex, country, and year (n=19,244) with a spatiotemporal Gaussian process regression model to estimate prevalence with 95% uncertainty intervals (UIs). Worldwide, the proportion of adults with a body-mass index (BMI) of 25 kg/m(2) or greater increased between 1980 and 2013 from 28·8% (95% UI 28·4-29·3) to 36·9% (36·3-37·4) in men, and from 29·8% (29·3-30·2) to 38·0% (37·5-38·5) in women. Prevalence has increased substantially in children and adolescents in developed countries; 23·8% (22·9-24·7) of boys and 22·6% (21·7-23·6) of girls were overweight or obese in 2013. The prevalence of overweight and obesity has also increased in children and adolescents in developing countries, from 8·1% (7·7-8·6) to 12·9% (12·3-13·5) in 2013 for boys and from 8·4% (8·1-8·8) to 13·4% (13·0-13·9) in girls. In adults, estimated prevalence of obesity exceeded 50% in men in Tonga and in women in Kuwait, Kiribati, Federated States of Micronesia, Libya, Qatar, Tonga, and Samoa. Since 2006, the increase in adult obesity in developed countries has slowed down. Because of the established health risks and substantial increases in prevalence, obesity has become a major global health challenge. Not only is obesity increasing, but no national success stories have been reported in the past 33 years. Urgent global action and leadership is needed to help countries to more effectively intervene. Bill & Melinda Gates Foundation. Copyright © 2014 Elsevier Ltd. All rights reserved.

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.

Heon Park, Zhaoxia Li, Xuexian O. Yang … (2005)

Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transcription factors required for T helper type 1 or type 2 differentiation. Furthermore, both IL-4 and interferon-gamma negatively regulated T helper cell production of IL-17 in the effector phase. In vivo, antibody to IL-17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused chemokine production and leukocyte infiltration. Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation.

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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

Jonathan R. Brestoff, Brian S Kim, Steven A Saenz … (2015)

Obesity is an increasingly prevalent disease regulated by genetic and environmental factors. Emerging studies indicate that immune cells, including monocytes, granulocytes and lymphocytes, regulate metabolic homeostasis and are dysregulated in obesity. Group 2 innate lymphoid cells (ILC2s) can regulate adaptive immunity and eosinophil and alternatively activated macrophage responses, and were recently identified in murine white adipose tissue (WAT) where they may act to limit the development of obesity. However, ILC2s have not been identified in human adipose tissue, and the mechanisms by which ILC2s regulate metabolic homeostasis remain unknown. Here we identify ILC2s in human WAT and demonstrate that decreased ILC2 responses in WAT are a conserved characteristic of obesity in humans and mice. Interleukin (IL)-33 was found to be critical for the maintenance of ILC2s in WAT and in limiting adiposity in mice by increasing caloric expenditure. This was associated with recruitment of uncoupling protein 1 (UCP1)(+) beige adipocytes in WAT, a process known as beiging or browning that regulates caloric expenditure. IL-33-induced beiging was dependent on ILC2s, and IL-33 treatment or transfer of IL-33-elicited ILC2s was sufficient to drive beiging independently of the adaptive immune system, eosinophils or IL-4 receptor signalling. We found that ILC2s produce methionine-enkephalin peptides that can act directly on adipocytes to upregulate Ucp1 expression in vitro and that promote beiging in vivo. Collectively, these studies indicate that, in addition to responding to infection or tissue damage, ILC2s can regulate adipose function and metabolic homeostasis in part via production of enkephalin peptides that elicit beiging.

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Author and article information

Contributors

Markus Kleinewietfeld:

ORCID: http://orcid.org/0000-0002-2832-3149

markus.kleinewietfeld@vib-uhasselt.be

Journal

Journal ID (nlm-ta): Immunology

Journal ID (iso-abbrev): Immunology

Journal ID (doi): 10.1111/(ISSN)1365-2567

Journal ID (publisher-id): IMM

Title: Immunology

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 0019-2805

ISSN (Electronic): 1365-2567

Publication date (Electronic): 24 March 2018

Publication date (Print): July 2018

Volume: 154

Issue: 3 ( doiID: 10.1111/imm.2018.154.issue-3 )

Pages: 346-353

Affiliations

[ ¹ ] VIB Laboratory of Translational Immunomodulation Center for Inflammation Research Biomedical Research Institute Hasselt University Diepenbeek Belgium

Author notes

[*] [* ] Correspondence: Markus Kleinewietfeld, VIB Laboratory of Translational Immunomodulation, Center for Inflammation Research, Hasselt University, Agoralaan building C, 3590 Diepenbeek, Belgium. Email: markus.kleinewietfeld@ 123456vib-uhasselt.be

Senior author: Prof. Dr. Markus Kleinewietfeld

Author information

Markus Kleinewietfeld http://orcid.org/0000-0002-2832-3149

Article

Accession ID: PMC6002217 Pmcid ID: PMC6002217 Pmc-uid ID: 6002217 Publisher ID: IMM12915

DOI: 10.1111/imm.12915

PMC ID: 6002217

PubMed ID: 29465812

SO-VID: bfc3b657-134e-435b-8da4-d236417057fc

History

Date received : 12 November 2017

Date revision received : 22 December 2017

Date accepted : 14 January 2018

Page count

Figures: 1, Tables: 1, Pages: 8, Words: 8004

Funding

Funded by: European Research Council (ERC)

Award ID: 640116

Funded by: SALK‐grant from the government of Flanders, Belgium

Funded by: Odysseus‐grant of the Research Foundation Flanders, Belgium (FWO)

Custom metadata

source-schema-version-number 2.0

component-id imm12915

cover-date July 2018

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.4.1.1 mode:remove_FC converted:14.06.2018

Keywords: T helper (TH) 17 cells,sodium chloride,regulatory T cell,diet,autoimmunity

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Keywords: T helper (TH) 17 cells, sodium chloride, regulatory T cell, diet, autoimmunity

The role of salt for immune cell function and disease

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Summary

Most cited references 58

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

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