Cathepsin S is associated with degradation of collagen I in abdominal aortic aneurysm.

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Abstract

Cathepsins have been described in the pathogenesis of abdominal aortic aneurysm (AAA), their exact role, especially in collagen degradation, is still unclear. The aim of the present study was therefore to analyse relevant cathepsins in human AAA tissue samples in relation to collagen I, III, and their degradation products.

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Cysteine cathepsins in the immune response.

T Zavasnik-Bergant, Nicholas B Turk-Browne (2006)

Antigen (Ag) processing by major histocompatibility complex class II (MHC) class II molecules is tightly linked with the proteases of the endosomal/lysosomal system. Cysteine (Cys) cathepsins, which constitute a major portion of this proteolytic system, have been found to have essential roles in both Ag processing and maturation of the MHC class II molecules. In this review, we will cover some specific functions of individual Cys cathepsins and particularly those most relevant to the immune system.

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G Ailawadi, JL Eliason, GR, Upchurch (2003)

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Histopathological analysis of cellular localization of cathepsins in abdominal aortic aneurysm wall.

F. Lohoefer, C Reeps, C. LIPP … (2012)

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Author and article information

Journal

Journal ID (iso-abbrev): VASA

Title: VASA. Zeitschrift fur Gefasskrankheiten

Publisher: Hogrefe Publishing Group

ISSN: 0301-1526

ISSN (Print): 0301-1526

Publication date (Electronic): Jun 2018

Volume: 47

Issue: 4

Affiliations

[1 ] 1 Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

[2 ] 2 University Centre for Vascular Medicine and Department of Vascular Surgery, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

[3 ] 3 Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.