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Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18.
Murali Ganesan
1
,
2 ,
Larisa Y Poluektova
3 ,
Dean J Tuma
1
,
2 ,
Kusum K Kharbanda
1
,
2 ,
Natalia A Osna
4
,
5
November 2016
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Abstract
Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV) infection and worsens disease outcomes. The exact reasons are not clear yet, but they might be partially attributed to the ability of alcohol to further suppress the innate immunity. Innate immunity is known to be already decreased by HCV in liver cells.