Modification of cut-off values for HE4, CA125 and the ROMA algorithm for early-stage epithelial ovarian cancer detection: Results from 1021 cases in South China.

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Abstract

The purpose of this study was to evaluate the performance of human epididymis protein 4 (HE4) and the Risk of Ovarian Malignancy Algorithm (ROMA) in early stage epithelial ovarian cancer (EOC) detection in patients in southern China. Additionally, this study proposes a possible ideal cut-off value for each marker to its own population in South China.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin Biochem

Title: Clinical biochemistry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2933

ISSN (Print): 0009-9120

Publication date (Electronic): Jan 2016

Volume: 49

Issue: 1-2

Affiliations

[1 ] Clinical Laboratory, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.

[2 ] Clinical Laboratory, Cancer Center of Sun Yat-Sen University, Guangzhou, 510060, People's Republic of China.

[3 ] Clinical Laboratory, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China. Electronic address: 1725012289@qq.com.

Article

Publisher Item ID: S0009-9120(15)00309-4

DOI: 10.1016/j.clinbiochem.2015.07.029

PubMed ID: 26285075

SO-VID: 68dbf351-4116-4a8a-94cf-18c371f64a9b

History

Keywords: CA125,Epithelial ovarian cancer,HE4,ROMA,South China

Data availability:

Keywords: CA125, Epithelial ovarian cancer, HE4, ROMA, South China

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