3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Thrombotic Microangiopathy and the Kidney

      research-article

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.

          Related collections

          Author and article information

          Journal
          Clin J Am Soc Nephrol
          Clin J Am Soc Nephrol
          clinjasn
          cjn
          CJASN
          Clinical Journal of the American Society of Nephrology : CJASN
          American Society of Nephrology
          1555-9041
          1555-905X
          7 February 2018
          17 October 2017
          : 13
          : 2
          : 300-317
          Affiliations
          [1 ]National Renal Complement Therapeutics Centre, Newcastle upon Tyne, Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK;
          [2 ]Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; and
          [3 ]Department of Cellular Pathology, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK
          Author notes
          Correspondence: Prof. David Kavanagh, National Renal Complement Therapeutics Centre, Atypical Haemolytic Uremic Syndrome Service, Building 26, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, United Kingdom. Email: david.kavanagh@ 123456newcastle.ac.uk
          Article
          PMC5967417 PMC5967417 5967417 00620117
          10.2215/CJN.00620117
          5967417
          29042465
          Copyright © 2018 by the American Society of Nephrology
          Page count
          Figures: 4, Tables: 5, Equations: 0, References: 129, Pages: 18
          Categories
          Glomerular Diseases: Update for the Clinician
          Custom metadata
          February 07, 2018

          Comments

          Comment on this article