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Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T.

Author(s): Gagan Joshi, Joseph Biederman, Janet Wozniak, Rachel L Goldin, Dave Crowley, Stephannie L Furtak, Scott E. Lukas, Atilla Gönenc

Publication date: 2013-07-31

Journal: European Archives of Psychiatry and Clinical Neuroscience

Keywords: Adolescent, Autistic Disorder, metabolism, pathology, Case-Control Studies, Child, Glutamic Acid, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Pilot Projects

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Abstract

The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 ± 1.8; age range: 12-17 years) with intact intellectual capacity (mean IQ: 108 ± 14.26; IQ range: 85-127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.