Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

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Abstract

Ezetimibe, when added to simvastatin, reduces cardiovascular events after acute coronary syndrome. We explored outcomes stratified by diabetes mellitus (DM).

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Author and article information

Journal

Journal ID (iso-abbrev): Circulation

Title: Circulation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4539

ISSN (Print): 0009-7322

Publication date (Electronic): April 10 2018

Volume: 137

Issue: 15

Affiliations

[1 ] TIMI Study Group, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., C.P.C., J.-G.P., E.A.B., E.B.). rgiugliano@partners.org.

[2 ] TIMI Study Group, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., C.P.C., J.-G.P., E.A.B., E.B.).

[3 ] Duke Clinical Research Institute, Department of Medicine, Durham, NC (M.A.B., J.A.W.).

[4 ] Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, HCFMUSP, Brazil (J.C.N.).

[5 ] División Enfermedades Cardiovasculares, Centro Médico Clínica, Santiago, Chile (R.C.).

[6 ] Internal Cardiology Department, University Hospital Brno, Czech Republic (J.S.).

Article

Publisher Item ID: CIRCULATIONAHA.117.030950

DOI: 10.1161/CIRCULATIONAHA.117.030950

PubMed ID: 29263150

SO-VID: 8457b9d7-84b8-47d8-8efc-f48922ea5472

History

Keywords: acute coronary syndromes,diabetes mellitus,ezetimibe,lipids

Data availability:

Keywords: acute coronary syndromes, diabetes mellitus, ezetimibe, lipids

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