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Abstract

A new bioactive compound of the N-acylhydrazone class, LASSBio-294, was shown to produce a cardioinotropic effect and vasodilation. In this study, we report the structure-based drug metabolism prediction, biosynthesis and identification of the major mammalian metabolite of LASSBio-294. Copyright 2010 Elsevier Ltd. All rights reserved.

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PubMed ID:: 20488703

DOI:: 10.1016/j.bmcl.2010.04.073

ScienceOpen disciplines: Chemistry

Keywords: Animals,Beauveria,metabolism,Cardiotonic Agents,Dogs,Hydrazones,Magnetic Resonance Spectroscopy,Molecular Structure,Thiophenes,Vasodilation,drug effects

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Beauveria, metabolism, Cardiotonic Agents, Dogs, Hydrazones, Magnetic Resonance Spectroscopy, Molecular Structure, Thiophenes, Vasodilation, drug effects

Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294.

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