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In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy
Author(s):
Alfonso Garcia-Bennett
,
Matthias Nees
,
Bengt Fadeel
Publication date
Created:
April 2011
Publication date
(Print):
April 2011
Journal:
Biochemical Pharmacology
Publisher:
Elsevier BV
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Abstract
Targeted drug therapy or "smart" drug delivery, potentially combined with simultaneous imaging modalities to monitor the delivery of drugs to specific tissues, is arguably the "holy grail" of pharmacology. Therapeutic approaches that exploit nanoparticles to deliver drugs selectively to cancer cells are currently considered one of the most promising avenues in the area of cancer therapeutics and imaging. The potential to deliver active chemotherapeutic drugs in the vicinity or directly within specific tumors via receptor mediated pathways, and to image tumors through the use of nanoparticles has been conceptually and experimentally shown for several classes of nanoparticles. Nanoparticles functionalized with the vitamin folic acid are of particular interest as a variety of malignant tumors are known to overexpress the folate receptor(s). Indeed, several nanoparticle architectures with improved retention time, administration route, biocompatibility, absorption, and clearance are being proposed and are in late stage clinical development. This commentary highlights some of the most important concepts related to nanoparticles and folate-mediated drug delivery and imaging in cancer research. Copyright © 2011 Elsevier Inc. All rights reserved.
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EU NanoSafety Cluster Publications: Journal Articles
Author and article information
Journal
Title:
Biochemical Pharmacology
Abbreviated Title:
Biochemical Pharmacology
Publisher:
Elsevier BV
ISSN (Print):
00062952
Publication date Created:
April 2011
Publication date (Print):
April 2011
Volume
: 81
Issue
: 8
Pages
: 976-984
Article
DOI:
10.1016/j.bcp.2011.01.023
SO-VID:
a3843c58-ebf7-4a41-aa1c-2ba064ce6405
Copyright ©
© 2011
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