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Cefiderocol as Rescue Therapy for Acinetobacter baumannii and Other Carbapenem-resistant Gram-negative Infections in Intensive Care Unit Patients.
Marco Falcone
1 ,
Giusy Tiseo
1 ,
Manuela Nicastro
2 ,
Alessandro Leonildi
3 ,
Alessandra Vecchione
3 ,
Costanza Casella
2 ,
Francesco Forfori
2
,
4 ,
Paolo Malacarne
2 ,
Fabio Guarracino
2 ,
Simona Barnini
3 ,
Francesco Menichetti
1
June 01 2021
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Abstract
Ten critically ill patients with either bacteremia or ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii, Stenotrophomonas maltophilia, or New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae received cefiderocol. All strains had minimum inhibitory concentration ≤2 μg/mL. Thirty-day clinical success and survival rates were 70% and 90%, respectively. Two patients had a microbiological failure. Future prospective studies are warranted.