Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.

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Abstract

A non-randomised, phase 2 study showed activity and tolerability of eribulin in advanced or metastatic soft-tissue sarcoma. In this phase 3 study, we aimed to compare overall survival in patients with advanced or metastatic soft-tissue sarcoma who received eribulin with that in patients who received dacarbazine (an active control).

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Apr 16 2016

Volume: 387

Issue: 10028

Affiliations

[1 ] Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address: patrick.schoffski@uzleuven.be.

[2 ] Sarcoma Oncology Center, Santa Monica, CA, USA.

[3 ] Tisch Cancer Institute, Mount Sinai Medical Center, New York, NY, USA.

[4 ] Department of Oncology, Institut Bergonié, Bordeaux, France.

[5 ] Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands.

[6 ] Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, USA.

[7 ] Department of Medical Oncology, Fondazione del Piemonte per I'Oncologia IRCCS, Candiolo, Italy.

[8 ] Department of Medical Oncology, Hospital Sírio-Libanês and Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil.

[9 ] West German Cancer Center, University of Duisburg-Essen, Essen, Germany.

[10 ] Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.

[11 ] Université Claude Bernard Lyon I, LYRIC INCa-DGOS 4664 & Centre Léon Bérard, Lyon, France.

[12 ] Division of Surgical Oncology & Thoracic Surgery, Department of Surgery, Mannheim University Medical Center, Mannheim, Germany.

[13 ] Eisai, Woodcliff Lake, NJ, USA.

[14 ] Department of Hematology, UCLA Jonsson Comprehensive Cancer, Los Angeles, CA, USA.

[15 ] Gustave Roussy, Villejuif, France.

[16 ] Sarcoma Center, Dana-Farber Cancer Institute and Ludwig Center at Harvard Medical School, Boston, MA, USA.

[17 ] Department of Sarcoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

Article

Publisher Item ID: S0140-6736(15)01283-0

DOI: 10.1016/S0140-6736(15)01283-0

PubMed ID: 26874885

SO-VID: 7c954809-faf1-4cf7-88ed-fd4271dff0ab

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