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Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability.

Author(s): Jay Luther, John J Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R Turner, Martin L Yarmush, Raymond T Chung, Suraj J Patel

Publication date: 2015-03-01

Journal: Cellular and molecular gastroenterology and hepatology

Publisher: Elsevier BV

Keywords: Tight Junctions, Steatosis, Myosin Light Chain Kinase, Meta-Analysis

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Abstract

Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have investigated the association between increased intestinal permeability and NASH. Our meta-analysis of this association investigates the underlying mechanism.

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PubMed ID:: 26405687

PMC ID:: 4578658

DOI:: 10.1016/j.jcmgh.2015.01.001

Keywords: Tight Junctions,Steatosis,Myosin Light Chain Kinase,Meta-Analysis

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Keywords: Tight Junctions, Steatosis, Myosin Light Chain Kinase, Meta-Analysis

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