Record: found
Abstract: found
Article: not found

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

Author(s): Elizabeth Fry, T von Lengerke, Charles Hutchins, Eric Lai, C. Abad, Melissa Daly, J Gum

Publication date: 2006-04-01

Journal: Bioorganic & Medicinal Chemistry Letters

Keywords: Allosteric Regulation, Animals, Enzyme Inhibitors, chemistry, pharmacokinetics, pharmacology, Fructose-Bisphosphatase, antagonists & inhibitors, Models, Molecular, Rats, Sulfonamides

Read this article at

ScienceOpenPublisher PubMed

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC(50) of 0.57microM. Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats.

Related collections

Author and article information

Journal

PubMed ID:: 16446092

DOI:: 10.1016/j.bmcl.2006.01.014

ScienceOpen disciplines: Chemistry

Keywords: Allosteric Regulation,Animals,Enzyme Inhibitors,chemistry,pharmacokinetics,pharmacology,Fructose-Bisphosphatase,antagonists & inhibitors,Models, Molecular,Rats,Sulfonamides

Data availability:

ScienceOpen disciplines: Chemistry

Keywords: Allosteric Regulation, Animals, Enzyme Inhibitors, chemistry, pharmacokinetics, pharmacology, Fructose-Bisphosphatase, antagonists & inhibitors, Models, Molecular, Rats, Sulfonamides

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

Read this article at

Abstract

Related collections

ChemSpider related publications

Author and article information

Journal

Comments

Comment on this article

Similar content 185

Cited by 13