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Abstract
The free radical scavenging and antihepatotoxic activity from Ganoderma lucidum, Ganoderma
formosanum and Ganoderma neo-japonicum were studied. Treatment with the water extract
of Ganoderma lucidum, Ganoderma formosanum and Ganoderma neo-japonicum caused a marked
decrease in the CCl4-induced toxicity in rat liver, made evident by their effect on
the levels of glutamic oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH)
in the serum. The scavenging potency of the water extracts of the crude drugs was
evaluated in terms of their ability to reduce the peaks of spin adducts using electron
spin resonance (ESR) spin-trapping techniques. The results indicated that Ganoderma
formosanum showed the greatest antihepatotoxic activity and the greatest free radical
scavenging activity.