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Anaphylactoid reactions during hemodialysis on AN69 membranes in patients receiving ACE inhibitors
Christian Tielemans ,
Philippe Madhoun ,
Michele Lenaers ,
Liliane Schandene ,
Michel Goldman ,
Jean-Louis Vanherweghem
November 1990
November 1990
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Abstract
We report five life-threatening anaphylactoid reactions occurring within the very
first minutes of hemodialysis on polyacrylonitrile (AN69) capillary dialyzers in three
patients receiving ACE inhibitors. Such reactions were not observed either in patients
treated with ACE inhibitors but dialyzed on other membranes (N = 9), nor in patients
on AN69 who did not receive ACE inhibitors (N = 19). These anaphylactoid reactions
could be due to bradykinin accumulation, as a result of both increased synthesis--by
interaction of blood with the AN69 polymer--and catabolism blockade by ACE inhibitors.