Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes.

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Abstract

In type 1 diabetes (T1D), adjuvant treatment with inhibitors of the renin-angiotensin-aldosterone system (RAAS), which dilate the efferent arteriole, is associated with prevention of progressive albuminuria and renal dysfunction. Uncertainty still exists as to why some individuals with long-standing T1D develop diabetic kidney disease (DKD) while others do not (DKD resistors). We hypothesized that those with DKD would be distinguished from DKD resistors by the presence of RAAS activation.

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Author and article information

Journal

Journal ID (iso-abbrev): JCI Insight

Title: JCI insight

Publisher: American Society for Clinical Investigation

ISSN (Electronic): 2379-3708

ISSN (Print): 2379-3708

Publication date (Electronic): Jan 11 2018

Volume: 3

Issue: 1

Affiliations

[1 ] Division of Endocrinology and Metabolism and.

[2 ] Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

[3 ] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

[4 ] Research Division, Barbara Davis Center for Diabetes, Aurora, Colorado, USA.

[5 ] Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.

[6 ] Department of Ophthalmology and Vision Sciences, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

[7 ] Joint Department of Medical Imaging, Division of Cardiothoracic Radiology, University Health Network, Toronto, Ontario, Canada.

[8 ] Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Krembil Neuroscience Centre, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Article

Publisher Item ID: 96968

DOI: 10.1172/jci.insight.96968

PMC ID: 5821172

PubMed ID: 29321380

SO-VID: 9348801c-1c02-4fa7-b2fb-24947cc6a199

History

Keywords: Endocrinology,Nephrology,Diabetes

Data availability:

Keywords: Endocrinology, Nephrology, Diabetes

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