Beta-Blockade Prevents Ventricular Failure following Aortic Regurgitation in Rabbits

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Abstract

This study investigated the effects of chronic β-blockade on the pathophysiology of heart failure following induction of aortic regurgitation (AR). Nine rabbits with AR were administered propranolol continuously for 7 days (AR+P), 8 rabbits with AR received vehicle for the same period (AR+C), and 7 rabbits underwent sham operation. Cardiac output was lower and the left-ventricular end-diastolic pressure was higher in AR+C than in sham-operated rabbits, but there was no difference in the right-ventricular end-diastolic pressure between the two groups. Down-regulation of β-adrenoceptors was observed in the left ventricle, but not in the right ventricle. All of these variables were reversed in AR+P. In left-ventricular failure produced by AR, (1) the augmentation of adrenergic drive occurred selectively in the left ventricle, and (2) propranolol blunted adrenergic drive and played a protective role against myocardial damage.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 19 November 2008

Volume: 88

Issue: 5

Pages: 418-424

Affiliations

^aCardiopulmonary Division, Department of, Medicine, School of Medicine, Keio University, and ^bFirst Department of Internal Medicine, Tokai University, Tokyo, Japan

Article

Publisher ID: 177371 Other ID: Cardiology 1997;88:418–424

DOI: 10.1159/000177371

PubMed ID: 9286503

SO-VID: e8aa6d0d-a126-4380-8f4a-028dd9a97ce4

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 11 March 1996

Date accepted : 30 July 1996

Page count

Pages: 7

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