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      Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

      Author(s): ,
      Publication date Created:
      Publication date (Print):
      Journal: The Journal of Antibiotics
      Publisher: Springer Nature

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          Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

          Lars Jordheim, David Durantel, Fabien Zoulim … (2013)
          Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections. The approval of several additional drugs over the past decade demonstrates that this family still possesses strong potential. Here, we review new nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to provide increased response rates and reduced side effects. We also highlight the different approaches used in the development of these drugs and the potential of personalized therapy.
          Article 0 comments Cited 277 times – based on 0 reviews     Review now
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            Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

            Renatus W. Sinkeldam, Nicholas J Greco, Yitzhak Tor (2010)
            Article 0 comments Cited 125 times – based on 0 reviews     Review now
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              Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.

              Jadd Shelton, Xiao Jie Lu, Joseph A Hollenbaugh … (2016)
              Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy have been treated with one or more of these analogs. This review focuses on the chemical synthesis and biology of anticancer nucleoside, nucleotide, and base analogs that are FDA-approved and in clinical development since 2000. We highlight the cellular biology and clinical biology of analogs, drug resistance mechanisms, and compound specificity towards different cancer types. Furthermore, we explore analog syntheses as well as improved and scale-up syntheses. We conclude with a discussion on what might lie ahead for medicinal chemists, biologists, and physicians as they try to improve analog efficacy through prodrug strategies and drug combinations.
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                Author and article information

                Journal
                Title: The Journal of Antibiotics
                Abbreviated Title: J Antibiot
                Publisher: Springer Nature
                ISSN (Print): 0021-8820
                ISSN (Electronic): 1881-1469
                Publication date Created: July 26 2017
                Publication date (Print): July 26 2017
                Volume:
                Issue:
                Article
                DOI: 10.1038/ja.2017.87
                SO-VID: c291d0b3-6503-4d6f-9727-d96f5a74ae0a
                Copyright © © 2017
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