Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

Demetri, George D; von Mehren, Margaret; Jones, Robin L.; Hensley, Martee L; Schuetze, Scott M; Staddon, Arthur; Milhem, Mohammed; Elias, Anthony D; Ganjoo, Kristen; Tawbi, Hussein A.; Van Tine, Brian A; Spira, Alexander; Dean, Andrew C.; Khokhar, Nushmia Z; Park, Youn Choi; Knoblauch, Roland E; Parekh, Trilok V; Maki, Robert G; Patel, Shreyaskumar R.

doi:10.1200/JCO.2015.62.4734

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Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

Author(s): George Demetri, Margaret von Mehren, Robin L. Jones, Martee Hensley, Scott Schuetze, Arthur Staddon, Mohammed Milhem, Anthony D Elias, Kristen Ganjoo, Hussein Tawbi, Brian A Van Tine, Alexander Spira, Andrew Dean, Nushmia Z Khokhar, Youn Choi Park, Roland Knoblauch, Trilok V Parekh, Robert G Maki, Shreyaskumar Patel

Publication date: 2016-03-10

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology

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Abstract

This multicenter study, to our knowledge, is the first phase III trial to compare trabectedin versus dacarbazine in patients with advanced liposarcoma or leiomyosarcoma after prior therapy with an anthracycline and at least one additional systemic regimen.

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PubMed ID:: 26371143

DOI:: 10.1200/JCO.2015.62.4734

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Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.

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