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      Full-field optical coherence tomography for the analysis of fresh unstained human lobectomy specimens.

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          Abstract

          Full-field optical coherence tomography (FFOCT) is a real-time imaging technique that generates high-resolution three-dimensional tomographic images from unprocessed and unstained tissues. Lack of tissue processing and associated artifacts, along with the ability to generate large-field images quickly, warrants its exploration as an alternative diagnostic tool.

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          High-resolution full-field optical coherence tomography with a Linnik microscope.

          L. Vabre, Jeffrey Dubois, Claude Boccara … (2002)
          We describe an original microscope for high-resolution optical coherence tomography applications. Our system is based on a Linnik interference microscope with high-numerical-aperture objectives. Lock-in detection of the interference signal is achieved in parallel on a CCD by use of a photoelastic birefringence modulator and full-field stroboscopic illumination with an infrared LED. Transverse cross-section (en-face, or XY) images can be obtained in real time with better than 1-microm axial (Z) resolution and 0.5-microm transverse (XY) resolution. A sensitivity of approximately 80 dB is reached at a 1-image/s acquisition rate, which allows tomography in scattering media such as biological tissues.
          Article 0 comments Cited 77 times – based on 0 reviews     Review now
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            Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography

            Linbo Liu, Kengyeh Chu, Grace Houser … (2013)
            We demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT captures several key parameters governing the function of the airway surface (airway surface liquid depth, periciliary liquid depth, ciliary function including beat frequency, and mucociliary transport rate) from the same series of images and without exogenous particles or labels, enabling non-invasive study of dynamic phenomena. Additionally, the high resolution of μOCT reveals distinguishable phases of the ciliary stroke pattern and glandular extrusion. Images and functional measurements from primary human bronchial epithelial cell cultures and excised tissue are presented and compared with measurements using existing gold standard methods. Active secretion from mucus glands in tissue, a key parameter of epithelial function, was also observed and quantified.
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              Ultrahigh-resolution full-field optical coherence tomography.

              Kate Grieve, L. Vabre, Romain Lecaque … (2004)
              We have developed a white-light interference microscope for ultrahigh-resolution full-field optical coherence tomography of biological media. The experimental setup is based on a Linnik-type interferometer illuminated by a tungsten halogen lamp. En face tomographic images are calculated by a combination of interferometric images recorded by a high-speed CCD camera. Spatial resolution of 1.8 microm x 0.9 microm (transverse x axial) is achieved owing to the extremely short coherence length of the source, the compensation of dispersion mismatch in the interferometer arms, and the use of relatively high-numerical-aperture microscope objectives. A shot-noise-limited detection sensitivity of 90 dB is obtained in an acquisition time per image of 4 s. Subcellular-level images of plant, animal, and human tissues are presented.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): J Pathol Inform
                Title: Journal of pathology informatics
                Publisher: Medknow
                ISSN: 2229-5089
                Publication date (Electronic): 2013
                Volume: 4
                Affiliations
                [1 ] Department of Urology, Weill Medical College of Cornell University, New York, USA ; Department of Biochemistry, Weill Medical College of Cornell University, New York, USA.
                Article
                Publisher Item ID: JPI-4-26
                DOI: 10.4103/2153-3539.119004
                PMC ID: 3814996
                PubMed ID: 24244883
                SO-VID: de220d19-316b-4fc4-b96e-5e801aba5cc9
                History

                Keywords: histopathology,neoplastic tissue,lobectomy,Full-field optical coherence tomography
                Data availability:
                Keywords: histopathology, neoplastic tissue, lobectomy, Full-field optical coherence tomography

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