The high prevalence of medication use increases the potential for medication overdoses, especially among children. This paper describes the burden of unintentional pediatric medication overdoses in order to target new prevention efforts. Data were analyzed in 2007 and 2008 from the National Electronic Injury Surveillance System, collected January 1, 2004, through December 31, 2005, to estimate the number of emergency department visits resulting from unintentional medication overdoses among children aged