Real-time tracking of self-reported symptoms to predict potential COVID-19

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Abstract

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those with a positive test result (4,668 of 7,178 individuals; 65.03%) than in those with a negative test result (2,436 of 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval = 6.31–7.21). A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19.

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Most cited references 8

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Waradon Sungnak, Ni Huang, Christophe Bécavin … (2020)

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Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

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Sudden and Complete Olfactory Loss Function as a Possible Symptom of COVID-19

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Author and article information

Journal

Journal ID (nlm-journal-id): 9502015

Journal ID (pubmed-jr-id): 8791

Journal ID (nlm-ta): Nat Med

Journal ID (iso-abbrev): Nat Med

Title: Nature medicine

ISSN (Print): 1078-8956

ISSN (Electronic): 1546-170X

Publication date Nihms-submitted: 12 December 2020

Publication date (Electronic): 11 May 2020

Publication date (Print): July 2020

Publication date PMC-release: 21 December 2020

Volume: 26

Issue: 7

Pages: 1037-1040

Affiliations

[1 ]Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.

[2 ]Academic Rheumatology, Clinical Sciences, Nottingham City Hospital, Nottingham, UK.

[3 ]School of Biomedical Engineering & Imaging Sciences, King’s College London, London, UK.

[4 ]Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

[5 ]Zoe Global, London, UK.

[6 ]NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, UK.

[7 ]These authors contributed equally: Cristina Menni, Ana M. Valdes.

[8 ]These authors jointly supervised this work: Claire J. Steves, Tim D. Spector.

Author notes

Author contributions

C.M., A.M.V., J.W., C.J.S. and T.D.S. conceived of and designed the experiments. C.M., M.B.F., C.H.S., S.G., and A.M.V. analyzed the data. T.V., S.O., M.J.C., R.C.E.B., A.V., J.S.E.S.-M., P.H., M.M., M.F., D.A.D., A.T.C. and L.H.N. contributed reagents, materials and/or analysis tools. C.M. and A.M.V. wrote the manuscript. All authors revised the manuscript.

[* ] Correspondence and requests for materials should be addressed to C.M. or T.D.S., cristina.menni@ 123456kcl.ac.uk ; tim.spector@ 123456kcl.ac.uk