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      Laryngeal and voice disorders in patients with gastroesophageal symptoms. Correlation with pH-monitoring.

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          Abstract

          To investigate laryngeal and voice disorders in patients with gastroesophageal symptoms and their correlation with pH-monitoring.

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          The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms.

          Roy C Orlando (2010)
          Heartburn is the most common and characteristic symptom of gastroesophageal reflux disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the esophageal mucosa and transmission of this peripheral signal to the central nervous system for cognition. Healthy esophageal epithelium provides an effective barrier between refluxed gastric acid and esophageal nociceptors; but this barrier is vulnerable to attack and damage, particularly by acidic gastric contents. How gastric acid is countered by defensive elements within the esophageal mucosa is a major focus of this discussion. When the defense is successful, the subject is asymptomatic and when unsuccessful, the subject experiences heartburn. Those with heartburn commonly fall into one of three endoscopic types: nonerosive reflux disease, erosive esophagitis and Barrett's esophagus. Although what determines endoscopic type remains unknown; it is proposed herein that inflammation plays a key, modulating role.
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            How does reflux affect laryngeal tissue quality? An experimental and histopathologic animal study.

            Mehmet Habesoglu, Tulay Erden Habesoglu, Pembegul Gunes … (2010)
            To investigate the histopathologic changes in intact laryngeal epithelium and mucosa exposed to endogenous gastric acid and pepsin in an experimental model of reflux.
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              Laryngopharyngeal symptoms and gastroesophageal reflux disease

              P Rouev, I Chakarski, D Doskov … (2005)
              Article 0 comments Cited 2 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Acta Cir Bras
                Title: Acta cirurgica brasileira
                ISSN (Electronic): 1678-2674
                ISSN (Print): 0102-8650
                Publication date (Electronic): Nov 2012
                Volume: 27
                Issue: 11
                Affiliations
                [1 ] Division of Otolaryngology, Department of Ophthalmology, Otolaryngology, Head and Neck Surgery, FMB, UNESP, Botucatu-SP, Brazil. rmartins@fmb.unesp.br
                Article
                Publisher Item ID: S0102-86502012001100013
                PubMed ID: 23117616
                SO-VID: d8ab25c5-9264-4f15-be2b-dcd7275675c6
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