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Abstract
The involvement of dopamine in maintaining intraocular pressure (IOP) was investigated
with the rabbit IOP recovery model after intravenous infusion of hypertonic saline.
Dopamine facilitated the IOP recovery while reserpine did the opposite. When dopamine
was administered after reserpinization, the IOP recovery was facilitated again. These
results indicate that dopamine is involved in the maintenance of IOP because depletion
of dopamine with reserpine resulted in an opposite effect produced by dopamine whereas
administration of dopamine in reserpinized animals induced dopaminergic responses.
Timolol produced similar effects as reserpine, which supports the idea that timolol
reduces aqueous humor formation through elimination of dopaminergic function and reduction
of blood flow in the ciliary body.