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      Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life.

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          Abstract

          Little is known about the pathogenic mechanisms of gluten immunogenicity in patients with celiac disease. We studied temporal associations between infections and the development of celiac disease autoimmunity, and examined effects of HLA alleles, rotavirus vaccination status, and infant feeding.

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          Author and article information

          Journal
          Clin. Gastroenterol. Hepatol.
          Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
          Elsevier BV
          1542-7714
          1542-3565
          May 2017
          : 15
          : 5
          Affiliations
          [1 ] Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida.
          [2 ] Health Informatics Institute, University of South Florida, Tampa, Florida.
          [3 ] Digestive Health Institute, Children's Hospital Colorado, University of Colorado, Denver; Barbara Davis Center, University of Colorado Denver, Aurora, Colorado.
          [4 ] Department of Virology, School of Medicine, University of Tampere, Tampere, Finland; Department of Dermatology, Tampere University Hospital, Tampere, Finland.
          [5 ] MediCity Laboratory, University of Turku, Turku, Finland.
          [6 ] Center for Infection and Immunity, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
          [7 ] Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany.
          [8 ] Pacific Northwest Diabetes Research Institute, Seattle, Washington.
          [9 ] Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
          [10 ] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
          [11 ] Department of Pediatrics, University of Turku, Turku, Finland; Departments of Physiology and Pediatrics, University of Turku, Turku, Finland.
          [12 ] Institute of Diabetes Research, Helmholtz Zentrum München, Klinikum Rechts der Isar, Technische Universität München, Forschergruppe Diabetes eV, Neuherberg, Germany.
          [13 ] National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
          [14 ] Department of Clinical Sciences, Lund University, Malmo, Sweden.
          [15 ] Department of Virology, School of Medicine, University of Tampere, Tampere, Finland; Department of Dermatology, Tampere University Hospital, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
          [16 ] Department of Clinical Sciences, Lund University, Malmo, Sweden. Electronic address: daniel.agardh@med.lu.se.
          Article
          S1542-3565(16)31043-6
          10.1016/j.cgh.2016.10.033
          27840181
          b5547619-bf33-4302-b97b-ba6d8cb39b6c
          History

          Autoimmunity,Food,Gastroenteritis,Rotavirus
          Autoimmunity, Food, Gastroenteritis, Rotavirus

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