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      Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E.

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          Abstract

          Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of reproductive toxicity of gossypol in rats and the protective effects of vitamin E. Forty Wistar rats were used, divided into four experimental groups (n = 10): DMSO/saline + corn oil; DMSO/saline + vitamin E; gossypol + corn oil; and gossypol + vitamin E.

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          Microsomal lipid peroxidation.

          J A Buege, S D Aust (1978)
          Article 0 comments Cited 754 times – based on 0 reviews     Review now
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            Free Radicals in Biology and Medicine

            Barry Halliwell, John M. C. Gutteridge (2007)
            Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research since its first publication in 1985. <br> This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), while maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of aging and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet. <br> This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
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              Gossypol Toxicity from Cottonseed Products

              Ivana Cristina N. Gadelha, Nayanna Brunna S. Fonseca, Silvia Catarina S. Oloris … (2014)
              Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins. However, gossypol toxicity limits cottonseed use in animal feed. High concentrations of free gossypol may be responsible for acute clinical signs of gossypol poisoning which include respiratory distress, impaired body weight gain, anorexia, weakness, apathy, and death after several days. However, the most common toxic effects is the impairment of male and female reproduction. Another important toxic effect of gossypol is its interference with immune function, reducing an animal's resistance to infections and impairing the efficiency of vaccines. Preventive procedures to limit gossypol toxicity involve treatment of the cottonseed product to reduce the concentration of free gossypol with the most common treatment being exposure to heat. However, free gossypol can be released from the bound form during digestion. Agronomic selection has produced cotton varieties devoid of glands producing gossypol, but these varieties are not normally grown because they are less productive and are more vulnerable to attacks by insects.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Biol. Res.
                Title: Biological research
                Publisher: Springer Science and Business Media LLC
                ISSN (Electronic): 0717-6287
                ISSN (Print): 0716-9760
                Publication date (Electronic): Jul 31 2015
                Volume: 48
                Affiliations
                [1 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. andreia_tieme@hotmail.com.
                [2 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. guelf_marieli@hotmail.com.
                [3 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. hyllanazootecnia@gmail.com.
                [4 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. marco.unesp@hotmail.com.
                [5 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. paulo.veiga22@bol.com.br.
                [6 ] Laboratory of Metabolic and Toxicological Biochemistry, UNESP-Univ Estadual Paulista, Rod. Comandante João Ribeiro de Barros (SP-294), km 651, Dracena, SP, 17900-000, Brazil. fmingatto@dracena.unesp.br.
                Article
                Publisher Item ID: 10.1186/s40659-015-0026-7
                DOI: 10.1186/s40659-015-0026-7
                PMC ID: 4521381
                PubMed ID: 26227499
                SO-VID: 4ab4ad88-a668-4dbc-abf5-a88cb975e2a1
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