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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance.
J F Caro
1 ,
J W Kolaczynski ,
M R Nyce ,
J P Ohannesian ,
I Opentanova ,
W H Goldman ,
R B Lynn ,
P L Zhang ,
M K Sinha ,
R V Considine
Jul 20 1996
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Abstract
A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid (CSF) production and the location of the blood/cerebrospinal-fluid barrier. Thus, this receptor might serve as a transporter for leptin. We have studied leptin concentrations in serum and (CSF).