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Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis.
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Abstract
Extracellular adenosine triphosphate (ATP) can act through the purinergic receptor subtype P2X3 to transmit a pain signal to the central nervous system. Bladder urothelial cells (BUCs) from patients with interstitial cystitis (IC) patients have augmented release of ATP during in vitro stretch. We queried whether P2X3 receptor subtype exists on cultured BUCs. Furthermore, we asked whether P2X3 expression can be altered by in vitro stretch and whether there exists a difference in expression between IC and control BUCs.