Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

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Abstract

The INTERCEPT Blood System (IBS) using amotosalen-HCl and ultraviolet (UV)A inactivates a large spectrum of microbial pathogens and white blood cells in therapeutic plasma. Our aim was to evaluate to what extent IBS modifies the capacity of plasma to generate thrombin and induces qualitative or quantitative modifications of plasma proteins.

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Journal

Journal ID (iso-abbrev): Transfusion

Title: Transfusion

Publisher: Wiley

ISSN (Electronic): 1537-2995

ISSN (Print): 0041-1132

Publication date (Electronic): September 2016

Volume: 56

Issue: 9

Affiliations

[1 ] UMR_S949, INSERM, Strasbourg, France.

[2 ] EFS-Alsace-Lorraine-Champagne-Ardenne, Strasbourg, France.

[3 ] Université de Strasbourg, Strasbourg, France.

[4 ] Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.

[5 ] Plateforme Protéomique 3P5, Université Paris Descartes, Sorbonne Paris Cité

[6 ] INSERM, U1016, Institut Cochin, Paris, France.

[7 ] CNRS, UMR 8104, Paris, France.

[8 ] Association ARMESA, Strasbourg, France.

[9 ] Association ARMESA, Strasbourg, France. jean-pierre.cazenave@armesa.org.

Article

DOI: 10.1111/trf.13670

PubMed ID: 27250038

SO-VID: 00367169-3caf-45b3-961d-fe41fe1774fd

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