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Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy.
Etienne Becht
1 ,
Aurélien de Reyniès
2 ,
Nicolas A Giraldo
1 ,
Camilla Pilati
3 ,
Bénédicte Buttard
1 ,
Laetitia Lacroix
1 ,
Janick Selves
4 ,
Catherine Sautès-Fridman
1 ,
Pierre Laurent-Puig
3 ,
Wolf Herman Fridman
5
Aug 15 2016
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Abstract
The tumor microenvironment is formed by many distinct and interacting cell populations, and its composition may predict patients' prognosis and response to therapies. Colorectal cancer is a heterogeneous disease in which immune classifications and four consensus molecular subgroups (CMS) have been described. Our aim was to integrate the composition of the tumor microenvironment with the consensus molecular classification of colorectal cancer.