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      Long-Term Follow-Up with Stress Echocardiograms of Patients with Kawasaki’s Disease


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          Patients with a history of Kawasaki’s disease (KD), particularly those not treated with intravenous γ-globulin, are at risk of coronary artery aneurysms and later obstruction. Twenty-eight patients with a history of KD (4 had coronary artery aneurysms) were examined with stress echocardiograms. Fourteen patients received γ-globulin ≤10 days of the onset, 8 patients received γ-globulin >10 days and 6 received no γ-globulin. The mean age at diagnosis was 7.2 ± 4.1 years; the median follow-up was 8.0 ± 7.4 years. All tests were negative. Using a binomial model, a power of 0.80, a sensitivity of each test of 80% and assuming uniform risk, the individual rate of failure to detect was <7%. At least 640 patients in each group would be needed to detect a difference of 3.5% vs. 7.0% and 184 in each group would be needed to detect a difference of 1.5% vs. 7.5%. We conclude that the probability of an abnormal stress echo in asymptomatic patients with a history of KD is at most 7% and that a more precise determination of the risk of an abnormal stress echo in KD requires a much larger study.

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          Author and article information

          S. Karger AG
          March 2002
          07 March 2002
          : 97
          : 1
          : 43-48
          aDepartment of Cardiology and bDepartment of Pediatric Cardiology, William Beaumont Hospital, Royal Oak, Mich., USA
          47418 Cardiology 2002;97:43–48
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 3, References: 13, Pages: 6
          Pediatric Cardiology


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