Brianna S. Ronnow a , Sandra P. Reyna a , Joseph B. Muhlestein a, b , Benjamin D. Horne a , Chloe A. Allen Maycock a , Tami L. Bair a , John F. Carlquist a, b , Abdallah G. Kfoury a , Jeffrey L. Anderson a, b , Dale G. Renlund a, b
04 October 2005
C-reactive protein (CRP) has been associated with atherosclerotic complications, and we hypothesized that CRP levels might also predict death in non-ischemic patients with left ventricular dysfunction. Two hundred and three patients with non-ischemic left ventricular dysfunction undergoing cardiac catheterization were included and were followed for 2.4 ± 1.4 years to determine the incidence of fatal events. Death occurred in 15% of patients with low CRP (1st and 2nd tertiles) and 30% of patients with high CRP (3rd tertile). After adjustment for 11 covariates, high CRP (p = 0.037, hazard ratio = 2.0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations.