Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults

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Abstract

Merkel cell polyomavirus (MCPyV) DNA was detected in 7 (1.3%) of 526 respiratory tract samples from patients in Australia with upper or lower respiratory tract symptoms. Partial T antigen and major capsid protein sequences of MCPyV identified in respiratory secretions showed high homology (99%–100%) to those found in Merkel cell carcinoma.

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Most cited references 6

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Bk virus: a clinical review.

M Reploeg, Gari Clifford, Gregory A Storch (2001)

We present a review of the clinically oriented literature about BK virus, a relative of JC virus, which is the etiologic agent of progressive multifocal leukoencephalopathy (PML). The kidney, lung, eye, liver, and brain have been proposed as sites of BK virus-associated disease, both primary and reactivated. BK virus has also been detected in tissue specimens from a variety of neoplasms. We believe that BK virus is most often permissively present in sites of disease in immunosuppressed patients, rather than being an etiologic agent that causes symptoms or pathologic findings. There is, however, strong evidence for BK virus-associated hemorrhagic cystitis and nephritis, especially in recipients of solid organ or bone marrow transplants. Now that BK virus can be identified by use of specific and sensitive techniques, careful evaluation of the clinical and pathologic presentations of patients with BK virus will allow us to form a clearer picture of viral-associated pathophysiology in many organ systems.

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Presence of the newly discovered human polyomaviruses KI and WU in Australian patients with acute respiratory tract infection

S Bialasiewicz, D.M. Whiley, S.B. Lambert … (2008)

Background Currently, the role of the novel human polyomaviruses, KI (KIV) and WU (WUV) as agents of human disease remains uncertain. Objectives We sought to determine the prevalence of these viruses and their rate of co-detection with other viral respiratory pathogens, in an Australian population. Study design Polymerase chain reaction assays previously described were used to examine the presence of KIV and WUV in 2866 respiratory specimens collected from January to December 2003 from Australian patients with acute respiratory infections. Results KIV and WUV were present in our population with an annual prevalence of 2.6% and 4.5%, respectively. There was no apparent seasonal variation for KIV, but a predominance of infection was detected during late winter to early summer for WUV. The level of co-infection of KIV or WUV with other respiratory viruses was 74.7% and 79.7%, respectively. Both viruses were absent from urine and blood specimens collected from a variety of patient sources. Conclusions KIV and WUV circulate annually in the Australian population. Although there is a strong association with the respiratory tract, more comprehensive studies are required to prove these viruses are agents causing respiratory disease.

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Role of human metapneumovirus, human coronavirus NL63 and human bocavirus in infants and young children with acute wheezing

Heidi Smuts, Lesley Workman, Heather J Zar (2008)

Abstract The role of the novel respiratory viruses, human metapneumovirus (hMPV), human coronavirus NL63 (HCoV NL63) and human bocavirus (HBoV), in wheezing illness in children has not been well studied, especially in Africa. The aim of this study was to investigate the prevalence of hMPV, HCoV NL63 and HBoV in South African children with acute wheezing. A prospective study of consecutive children presenting with acute wheezing to a pediatric hospital from May 2004 to November 2005 was undertaken. A nasal swab was taken for reverse transcription‐polymerase chain reaction (RT‐PCR) and PCR for hMPV, HCoV NL63 and HBoV; when positive, the genes were sequenced. Shell vial culture for RSV, influenza A and B viruses, adenovirus and parainfluenza viruses 1, 2, 3 was performed on every 5th sample. Two hundred and forty two nasal swabs were collected from 238 children (median age 12.4 months). A novel respiratory virus was found in 44/242 (18.2%). hMPV, HBoV, and HCoV NL63 was found in 20 (8.3%), 18 (7.4%), and 6 (2.4%) of samples, respectively. Fifteen of 59 (25%) samples were positive for other respiratory viruses. Viral co‐infections, occurred in 6/242 (2.5%). Phylogenetic analysis showed co‐circulation of hMPV and HCoV NL63 A and B lineages, although only HBoV genotype st2 was found. Viruses are an important cause of wheezing in preschool children; hMPV, HCoV NL63, and HBoV are less common than the usual respiratory pathogens. J. Med. Virol. 80:906–912, 2008. © 2008 Wiley‐Liss, Inc.

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Author and article information

Journal

Journal ID (nlm-ta): Emerg Infect Dis

Journal ID (publisher-id): EID

Title: Emerging Infectious Diseases

Publisher: Centers for Disease Control and Prevention

ISSN (Print): 1080-6040

ISSN (Electronic): 1080-6059

Publication date (Print): March 2009

Volume: 15

Issue: 3

Pages: 492-494

Affiliations

[1]Sir Albert Sakzewski Virus Research Centre, Brisbane, Queensland, Australia (S. Bialasiewicz, S.B. Lambert, D.M. Whiley, M.D. Nissen, T.P. Sloots)

[2]University of Queensland Clinical Medical Virology Center, Brisbane (S. Bialasiewicz, S.B. Lambert, D.M. Whiley, M.D. Nissen, T.P. Sloots)

[3]Pathology Queensland; Brisbane (M.D. Nissen, T.P. Sloots)

Author notes

Address for correspondence: Seweryn Bialasiewicz, Queensland Pediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children’s Hospital and Health Service, District Herston Rd, Herston, Queensland, Australia 4029; email: seweryn@ 123456uq.edu.au

Article

Publisher ID: 08-1067

DOI: 10.3201/eid1503.081067

PMC ID: 2681122

PubMed ID: 19239774

SO-VID: 0139a6ed-67d8-4627-8f1c-605e591944af

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Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults

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European Respiratory Society: COVID-19

Most cited references 6

Bk virus: a clinical review.

Presence of the newly discovered human polyomaviruses KI and WU in Australian patients with acute respiratory tract infection

Role of human metapneumovirus, human coronavirus NL63 and human bocavirus in infants and young children with acute wheezing

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