Fear extinction in 17 day old rats is dependent on metabotropic glutamate receptor 5 signaling.

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Abstract

We used pharmacological modulation of the mGlu5 receptor to investigate its role in the extinction of conditioned fear throughout development. In postnatal day (P) 17 rats, the positive allosteric modulator CDPPB facilitated, while the negative allosteric modulator MTEP impaired extinction. These drugs had no such effects on P24 or adult rats. These results establish a changing importance of mGlu5 in extinction of conditioned fear at distinct stages of development.

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Author and article information

Journal

Journal ID (iso-abbrev): Behav. Brain Res.

Title: Behavioural brain research

Publisher: Elsevier BV

ISSN (Electronic): 1872-7549

ISSN (Print): 0166-4328

Publication date (Electronic): Feb 01 2016

Volume: 298

Issue: Pt A

Affiliations

[1 ] Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: despina.ganella@florey.edu.au.

[2 ] Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.

[3 ] Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.

[4 ] Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: drjeehyunkim@gmail.com.

Article

Publisher Item ID: S0166-4328(14)00795-5

DOI: 10.1016/j.bbr.2014.12.010

PubMed ID: 25497704

SO-VID: 0142c854-b671-40f8-934f-8bced03ddf6a

History

Keywords: CDPPB,Development,Extinction,Fear,MTEP,Mglu5

Data availability:

Keywords: CDPPB, Development, Extinction, Fear, MTEP, Mglu5

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