Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma?

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Abstract

Clear cell hidradenoma (CCH) is an uncommon adnexal tumor usually arising from eccrine glands and commonly seen on the face and the upper extremities. CCH occurring in the breast is extremely rare. Herein we report a case of MAML2-rearranged CCH of breast with a papillary architecture closely mimicking intraductal papilloma, adenomyoepithelioma and low-grade mucoepidermoid carcinoma, thus representing a source of diagnostic confusion. An overview of salient histologic features and immunophenotypes to distinguish CCH and low-grade mucoepidermoid carcinoma is also integrated into the report.

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Journal

Journal ID (iso-abbrev): Pathol Res Pract

Title: Pathology, research and practice

Publisher: Elsevier BV

ISSN (Electronic): 1618-0631

ISSN (Print): 0344-0338

Publication date (Electronic): Oct 2020

Volume: 216

Issue: 10

Affiliations

[1 ] Department of Pathology, University of Alabama at Birminham, Birmingham, AL, United States.

[2 ] Department of Pathology, University of Alabama at Birminham, Birmingham, AL, United States. Electronic address: swei@uabmc.edu.

Article

Publisher Item ID: S0344-0338(20)31995-6

DOI: 10.1016/j.prp.2020.153140

PubMed ID: 32853960

SO-VID: 0184f158-c84b-48dc-9179-e95e8a4ae26c

History

Keywords: Breast,Carcinoma,Clear cell hidradenoma,MAML2,Mucoepidermoid

Data availability:

Keywords: Breast, Carcinoma, Clear cell hidradenoma, MAML2, Mucoepidermoid

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