Michael G. Levin:
ORCID: http://orcid.org/0000-0002-9937-9932
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: Writing – original draftRole: Writing – review & editing
Renae Judy: Role: Data curationRole: Project administrationRole: ResourcesRole: Writing – review
& editing
Dipender Gill:
ORCID: http://orcid.org/0000-0001-7312-7078
Role: MethodologyRole: Writing – review & editing
Marijana Vujkovic:
ORCID: http://orcid.org/0000-0003-4924-5714
Role: MethodologyRole: Writing – review & editing
Shefali S. Verma:
ORCID: http://orcid.org/0000-0001-5216-4670
Role: Data curationRole: Writing – review & editing
Yuki Bradford: Role: Data curationRole: Writing – review & editing
Marylyn D. Ritchie:
ORCID: http://orcid.org/0000-0002-1208-1720
Role: Data curationRole: Writing – review & editing
Matthew C. Hyman:
ORCID: http://orcid.org/0000-0002-4050-6925
Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Saman Nazarian:
ORCID: http://orcid.org/0000-0002-8369-0259
Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Daniel J. Rader:
ORCID: http://orcid.org/0000-0002-9245-9876
Role: ConceptualizationRole: ResourcesRole: Writing – review & editing
Benjamin F. Voight:
ORCID: http://orcid.org/0000-0002-6205-9994
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Scott M. Damrauer:
ORCID: http://orcid.org/0000-0001-8009-1632
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
SupervisionRole: Writing – review & editing
Michiel Rienstra: Role: Academic Editor
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
8
October
2020
Publication date Collection:
October
2020
Volume: 17
Issue: 10
Electronic Location Identifier: e1003288
Affiliations
[1
]
Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of
Medicine, Philadelphia, Pennsylvania, United States of America
[2
]
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia,
Pennsylvania, United States of America
[3
]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, United
States of America
[4
]
Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia,
Pennsylvania, United States of America
[5
]
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College
London, London, United Kingdom
[6
]
Centre for Pharmacology & Therapeutics, Department of Medicine, Imperial College London,
London, United Kingdom
[7
]
Novo Nordisk Research Centre Oxford, Oxford, United Kingdom
[8
]
Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical
Education and Institute for Infection and Immunity, St George’s, University of London,
London, United Kingdom
[9
]
Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George’s University
Hospitals NHS Foundation Trust, London, United Kingdom
[10
]
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia,
Pennsylvania, United States of America
[11
]
Institute for Biomedical Informatics, University of Pennsylvania Perelman School of
Medicine, Philadelphia, Pennsylvania, United States of America
[12
]
Tarrytown, New York, United States of America
[13
]
Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
[14
]
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
University of Groningen, University Medical Center Groningen, NETHERLANDS
Author notes
The authors have declared that no competing interests exist.
¶ Membership of the Regeneron Genetics Center is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PMEDICINE-D-20-00041
DOI: 10.1371/journal.pmed.1003288
PMC ID: 7544133
PubMed ID: 33031386
SO-VID: 01a5eae5-8c68-49d0-b86d-9ef98051d52b
Copyright © © 2020 Levin et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000062, National Institute of Diabetes and Digestive and Kidney Diseases;
Award ID: R01-DK101478
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6205-9994
Benjamin F. Voight
Funded by: funder-id http://dx.doi.org/10.13039/100000738, U.S. Department of Veterans Affairs;
Award ID: IK2-CX001780
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8009-1632
Scott M. Damrauer
Funded by: Wellcome Trust (GB)
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7312-7078
Dipender Gill
Funded by: funder-id http://dx.doi.org/10.13039/100007928, Perelman School of Medicine, University of Pennsylvania;
Award ID: Linda Pechenik Montague Investigator Award
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6205-9994
Benjamin F. Voight
BFV was supported by the National Institute of Diabetes and Digestive and Kidney Diseases
(R01-DK101478;
https://www.niddk.nih.gov/) and a Linda Pechenik Montague Investigator Award (upenn.edu). SMD was supported
by the US Department of Veterans Affairs (IK2-CX001780; VA.gov). This publication
does not represent the views of the Department of Veterans Affairs or the United States
government. DG was supported by funding from the Wellcome Trust (
https://wellcome.ac.uk/). Genetic sequencing of Penn Medicine Biobank participants was performed in collaboration
with Regeneron Genetics Center (
https://www.regeneron.com/genetics-center), who also reviewed the manuscript but had no role in study design, data analysis,
or decision to publish. The other funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Arrhythmia
Subject:
Atrial Fibrillation
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Cardiovascular Medicine
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetics of Disease
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Cardiovascular Diseases
Subject:
Coronary Heart Disease
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Cardiovascular Medicine
Subject:
Cardiovascular Diseases
Subject:
Coronary Heart Disease
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Coronary Heart Disease
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Genome-Wide Association Studies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Genome-Wide Association Studies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Human Genetics
Subject:
Genome-Wide Association Studies
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Instrumental Variable Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Instrumental Variable Analysis
