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Correlation between CD4+CD28null T lymphocytes, regulatory T cells and plaque rupture: An Optical Coherence Tomography study in Acute Coronary Syndromes
Aureliano Ruggio ,
Daniela Pedicino ,
Davide Flego ,
Rocco Vergallo ,
Anna Severino ,
Claudia Lucci ,
Giampaolo Niccoli ,
Carlo Trani ,
Francesco Burzotta ,
Cristina Aurigemma ,
Antonio Maria Leone ,
Antonino Buffon ,
Alessia D'Aiello ,
Luigi Marzio Biasucci ,
Filippo Crea ,
Giovanna Liuzzo
September 2018
September 2018
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Abstract
A sizeable proportion of patients with Acute Coronary Syndromes (ACS) shows a unique
adaptive immune system profile, associated to a worse outcome, characterized by higher
CD4+CD28null T-cells, lower regulatory T-cells (Treg) and increased CD4+CD28null/Treg
ratio. We sought to investigate the correlation between CD4+CD28null T-cells, Treg,
CD4+CD28null/Treg ratio and plaque phenotype as assessed by Optical Coherence Tomography
(OCT).