Prediction of post-treatment retinal sensitivity by baseline retinal perfusion density measurements in eyes with branch retinal vein occlusion

Abstract

In this study, we investigated the longitudinal correlation between macular sensitivity and perfusion density (PD) in retinas affected by branch retinal vein occlusion. Retinal sensitivity was measured using microperimetry and PD was measured by optical coherence tomography angiography. We also investigated the possibility that the PD, 1 month after anti-vascular endothelial growth factor (VEGF) treatment, is a predictor of retinal sensitivity after 1 year of successful macular oedema management with anti-VEGF. The correlation between measurements of retinal sensitivity and PD at baseline (1 M) and at 6 and 12 months were investigated. There was a significant positive correlation between retinal sensitivity and PD at all time points (baseline (1 M), r = 0.67, P < 0.0001; 6 months, r = 0.59, P < 0.0001; 12 months, r = 0.62, P < 0.0001) and between the PD at 1 month and retinal sensitivity at 12 months (r = 0.63, P < 0.0001). Unlike in areas that showed a mild to moderate decline in PD, retinal sensitivity in areas where the decrease in PD was severe at baseline did not show significant improvement with treatment over time. These findings suggest that the PD value measured using optical coherence tomography angiography at or soon after the baseline can predict retinal sensitivity after 1 year of anti-VEGF treatment.