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      Long-term results of posterior cruciate ligament tear with or without reconstruction: A nationwide, population-based cohort study

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          Abstract

          Background

          There is increasing interest in the long-term outcomes of patients with posterior cruciate ligament (PCL) tears following conservative treatment or reconstruction. However, limited information is available regarding these results because of the relative rarity of cases and lack of long-term follow-up.

          Purpose

          The goals of this study are to (1) compare the occurrence of secondary meniscal tears, osteoarthritis (OA) or subsequent total knee replacement (TKR) in patients with or without PCL injury, and (2) evaluate the potential protective effect of PCL reconstruction against long-term sequela in patients with PCL deficiency.

          Study design

          Cohort study; Level of evidence, 3

          Methods

          This retrospective cohort study evaluated the long-term results of PCL deficiency with or without reconstruction in Taiwan based on data from the National Health Insurance Research Database (NHIRD) from 2000 to 2015. The cumulative incidence rates of meniscus tear, OA and TKR were analyzed using the Kaplan-Meier estimator. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

          Results

          A total of 4,169 patients diagnosed with PCL tear from 2000 to 2015 in Taiwan were included in the study. There was a higher cumulative incidence of meniscus tear (1.13%), OA (2.71%) and subsequent TKR (0.91%) among patients with a PCL tear than among patients without one (0.22%, 1.90%, 0.62%; all p < 0.05). PCL reconstruction patients had a decreased cumulative incidence of meniscus tear (0.41%), OA (2.30%) and subsequent TKR (0.48%) compared with non-reconstructed patients (2.44%, 3.46%, 1.69%; all p < 0.05). After adjusting for covariates, PCL-injured patients who underwent reconstruction within one year after PCL injury showed a significantly lower risk of subsequent sequelae than those who never underwent reconstruction (within 1 month: adjusted HR = 0.390, 95% CI = 0.284–0.535; 1 month to 1 year: adjusted HR = 0.546, 95% CI = 0.398–0.748).

          Conclusions

          Patients with PCL tears have a significantly higher risk of meniscus tear, OA and subsequent TKR than patients without PCL tears. PCL reconstruction could decrease the cumulative incidence of these outcomes. The results suggest that PCL-injured patients should undergo reconstruction as early as possible (within one year) to reduce the risk of further degeneration.

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          Most cited references34

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          Emerging Updates on the Posterior Cruciate Ligament: A Review of the Current Literature.

          The posterior cruciate ligament (PCL) is recognized as an essential stabilizer of the knee. However, the complexity of the ligament has generated controversy about its definitive role and the recommended treatment after injury. A proper understanding of the functional role of the PCL is necessary to minimize residual instability, osteoarthritic progression, and failure of additional concomitant ligament graft reconstructions or meniscal repairs after treatment. Recent anatomic and biomechanical studies have elucidated the surgically relevant quantitative anatomy and confirmed the codominant role of the anterolateral and posteromedial bundles of the PCL. Although nonoperative treatment has historically been the initial treatment of choice for isolated PCL injury, possibly biased by the historically poorer objective outcomes postoperatively compared with anterior cruciate ligament reconstructions, surgical intervention has been increasingly used for isolated and combined PCL injuries. Recent studies have more clearly elucidated the biomechanical and clinical effects after PCL tears and resultant treatments. This article presents a thorough review of updates on the clinically relevant anatomy, epidemiology, biomechanical function, diagnosis, and current treatments for the PCL, with an emphasis on the emerging clinical and biomechanical evidence regarding each of the treatment choices for PCL reconstruction surgery. It is recommended that future outcomes studies use PCL stress radiographs to determine objective outcomes and that evidence level 1 and 2 studies be performed to assess outcomes between transtibial and tibial inlay reconstructions and also between single- and double-bundle PCL reconstructions.
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            Epidemiology of posterior cruciate ligament injuries.

            The epidemiology of posterior cruciate ligament (PCL) injuries has not been well clarified. Isolated and combined PCL injuries are a frequently missed diagnosis. A better understanding of typical injury mechanisms may help in more accurate diagnosis of these injuries. In this study the epidemiology of PCL insufficiency in 494 patients was retrospectively analysed. Stress-radiography was used to quantify posterior tibial displacement. The mean age at the time of injury was 27.5+/-9.9 years. Traffic accidents (45%) and athletic injuries (40%) were the most common injury causes. Motorcycle accidents (28%) and soccer-related injuries (25%) accounted for the main specific injury causes. The most common injury mechanisms were dashboard injuries (35%) and falls on the flexed knee with the foot in plantar flexion (24%). The mean side-to-side difference of posterior tibial displacement on posterior stress-radiographs in 90 degrees of flexion was 13.4+/-4.7 mm. According to the posterior displacement values, 232 (47%) patients had isolated PCL ruptures, while 262 (53%) patients with a posterior displacement of >12 mm were classified as having a combined posterior instability. There were significantly more combined PCL lesions due to vehicular trauma as compared with athletic trauma ( p<0.0001). In many PCL lesions, initiation of an adequate treatment regimen is delayed despite typical injury mechanisms and symptoms. In the future, a better understanding of the epidemiology of PCL injuries should enable us to diagnose the injury more reliably through a detailed history and a thorough physical and radiographic examination in the acute setting.
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              The natural history of acute, isolated, nonoperatively treated posterior cruciate ligament injuries. A prospective study.

              We sought to determine prospectively the natural history of acute, isolated, nonoperatively treated posterior cruciate ligament injuries in athletically active patients. The study population consisted of 133 patients (average age, 25.2 years at time of injury). All patients completed a subjective questionnaire each year for an average of 5.4 years (range, 2.3 to 11.4). Sixty-eight of the 133 patients returned to the clinic for long-term follow-up evaluation. Objectively, physical examination revealed no change in laxity from initial injury to follow-up. No correlation was found between radiographic joint space narrowing and grade of laxity. The mean modified Noyes knee score was 84.2 points, the mean Lysholm score was 83.4, and the mean Tegner activity score was 5.7. Patients with greater laxity did not have worse subjective scores. No correlation was found between subjective knee scores and time from injury. Regardless of the amount of laxity, half of the patients returned to the same sport at the same or higher level, one-third returned to the same sport at a lower level, and one-sixth did not return to the same sport. Results of this study suggest that athletically active patients with acute isolated posterior cruciate ligament tears treated nonoperatively achieved a level of objective and subjective knee function that was independent of the grade of laxity.
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                Author and article information

                Contributors
                Role: ResourcesRole: Writing – original draft
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: SoftwareRole: SupervisionRole: Validation
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Methodology
                Role: MethodologyRole: Resources
                Role: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: MethodologyRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                3 October 2018
                2018
                : 13
                : 10
                : e0205118
                Affiliations
                [1 ] Department of Orthopaedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
                [2 ] Graduate Institute of Medical Science², National Defense Medical Center, Taipei, Taiwan, R.O.C.
                [3 ] School of Public Health, National Defense Medical Center, Taipei, Taiwan, R.O.C.
                [4 ] Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
                Mayo Clinic Minnesota, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0001-9577-820X
                Article
                PONE-D-18-22294
                10.1371/journal.pone.0205118
                6169976
                30281658
                02e3161c-9231-4231-9105-396a7f4bed3b
                © 2018 Wang et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 27 July 2018
                : 13 September 2018
                Page count
                Figures: 2, Tables: 4, Pages: 14
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/501100010425, Tri-Service General Hospital;
                Award ID: ATSGH-C107-080
                Award Recipient :
                This study was funded by Tri-Service General Hospital Research Foundation (TSGHATSGH- C107-080). The funder has no role in the design, concept, data collection and interpretation, analysis, drafting or other process in this paper.
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Musculoskeletal System
                Limbs (Anatomy)
                Legs
                Knees
                Medicine and Health Sciences
                Anatomy
                Musculoskeletal System
                Limbs (Anatomy)
                Legs
                Knees
                Medicine and Health Sciences
                Rheumatology
                Arthritis
                Osteoarthritis
                Biology and Life Sciences
                Anatomy
                Biological Tissue
                Connective Tissue
                Ligaments
                Medicine and Health Sciences
                Anatomy
                Biological Tissue
                Connective Tissue
                Ligaments
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Musculoskeletal System Procedures
                Joint Replacement Surgery
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Plastic Surgery and Reconstructive Techniques
                Biology and Life Sciences
                Anatomy
                Biological Tissue
                Connective Tissue
                Cartilage
                Medicine and Health Sciences
                Anatomy
                Biological Tissue
                Connective Tissue
                Cartilage
                Social Sciences
                Economics
                Health Economics
                Health Insurance
                Medicine and Health Sciences
                Health Care
                Health Economics
                Health Insurance
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