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      Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.

      Statistics in Medicine

      Humans, Meta-Analysis as Topic, Survival Analysis, Proportional Hazards Models, Randomized Controlled Trials as Topic

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          Abstract

          Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival-type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.

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          9921604

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