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Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer.
Jack Cuzick
1 ,
Mitch Dowsett ,
Silvia Pineda ,
Christopher Wale ,
Janine Salter ,
Emma Quinn ,
Lila Zabaglo ,
Elizabeth Mallon ,
Andrew R Green ,
Ian O Ellis ,
Anthony Howell ,
Aman U Buzdar ,
John F Forbes
Nov 10 2011
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Abstract
We recently reported that the mRNA-based, 21-gene Genomic Health recurrence score (GHI-RS) provided additional prognostic information regarding distant recurrence beyond that obtained from classical clinicopathologic factors (age, nodal status, tumor size, grade, endocrine treatment) in women with early breast cancer, confirming earlier reports. The aim of this article is to determine how much of this information is contained in standard immunohistochemical (IHC) markers.