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      Effects of Left Bundle Branch Block on Left Ventricular Function in Apparently Normal Subjects

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          Abstract

          To determine the independent effects of left bundle branch block (LBBB) on global and regional left ventricular (LV) function we performed equilibrium radionuclide angiocardiography at rest in 3 patients with chronic LBBB (group I, mean age 53.6 years and in 6 patients with intermittent LBBB (group II, mean age 41.5 years). All patients were judged to have an apparently normal heart. In 2 of 3 patients of group I a LV ejection fraction lower than 50% was observed, and in all 3 patients septal motion abnormalities were present. In all patients of group II the global LV ejection fraction was normal during normal conduction and decreased during LBBB; the inferoapical regional ejection fraction decreased in 5 of 6 cases and the posterolateral regional ejection fraction in 3 of 6 cases. Moreover, septal hypokinesis was observed both during normal and abnormal conduction in all group II patients. These findings seem to confirm that LBBB, chronic or intermittent, is able to deteriorate LV performance at rest, even in patients with an otherwise normal heart.

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          Author and article information

          Journal
          Journal ID (publisher-id): CRD
          Journal ID (nlm-ta): Cardiology
          Journal ID (doi): 10.1159/issn.0008-6312
          Title: Cardiology
          Publisher: S. Karger AG
          ISSN (Print): 0008-6312
          ISSN (Electronic): 1421-9751
          Publication date Subscription-year: 1988
          Publication date (Print): 1988
          Publication date (Electronic): 11 November 2008
          Volume: 75
          Issue: 5
          Pages: 365-371
          Affiliations
          aDipartimento di Medicina Interna, II Università degli Studi di Roma; bServizio di Medicina Nucleare, Istituto di I Clinica Medica, I Università degli Studi di Roma, Italia
          Article
          Publisher ID: 174400 Other ID: Cardiology 1988;75:365–371
          DOI: 10.1159/000174400
          PubMed ID: 2853003
          SO-VID: 036419f8-0c6e-4690-91fc-490601e1970f
          Copyright © © 1988 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 20 August 1987
          Date accepted : 11 April 1988
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Left ventricular function,Radionuclide studies,Left bundle branch block
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Left ventricular function, Radionuclide studies, Left bundle branch block

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