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      Long-term viability of allogenic donor stroma


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          We report the clinical history and histopathology of the longest known postoperative course of a myopic cornea lenticule implanted via epikeratoplasty that also had been subjected to excimer laser and mitomycin. Despite the mechanical and photochemical processes the allogenic cornea stroma had sustained, it is notable that it retained structural integrity and clarity. This report affirms the potential long-term clarity and resilience of allogenic stromal cornea and supports its use as a potential stabilizing option in cornea allogenic intrastromal ring segments for keratoconus and variations thereof for other cornea disorders.

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          Most cited references10

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          Corneal Allogenic Intrastromal Ring Segments (CAIRS) Combined With Corneal Cross-linking for Keratoconus

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            Long-term outcome of epikeratophakia

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              Epikeratophakia for keratoconus. The nationwide study.

              The nationwide study of epikeratophakia for the treatment of keratoconus involved 69 surgeons in the United States; they operated on 177 eyes as of Dec 31, 1985. In this first report, the results from 35 surgeons involving 82 cases with 30 or more days of follow-up after suture removal are described. In all but two patients, uncorrected visual acuity improved; 17 patients showed improvement of three Snellen lines, and 38 patients showed improvement of four or more lines. The majority of patients' vision returned to within one line of their best corrected acuity; in 78% it was 20/40 or better postoperatively. Eight patients needed no postoperative overrefraction at all. The mean flattening by keratometry readings was 9.36 diopters, and the mean decrease in myopia in terms of spherical equivalent was 5.26 D. No significant changes in intraocular pressure or endothelial cell counts were noted. Some advantages of epikeratophakia for keratoconus over the traditional penetrating keratoplasty include the lack of serious, vision-threatening complications or permanent vision loss, the reversible nature of the surgery, and the absence of potential immunogenic rejection phenomena.

                Author and article information

                Indian J Ophthalmol
                Indian J Ophthalmol
                Indian Journal of Ophthalmology
                Wolters Kluwer - Medknow (India )
                December 2020
                23 November 2020
                : 68
                : 12
                : 3057-3059
                [1 ]Department of Ophthalmology, Minneapolis VA Health Care System, Minneapolis, MN, USA
                [2 ]Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA
                [3 ]University of Minnesota Medical School, Minneapolis, MN, USA
                [4 ]Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA
                [5 ]Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
                Author notes
                Correspondence to: Mr. Christopher Santilli, 2085 Royale Dr., Eagan, MN - 55122, USA. E-mail: santi145@ 123456umn.edu
                Copyright: © 2020 Indian Journal of Ophthalmology

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                : 15 April 2020
                : 05 July 2020
                : 11 July 2020
                Case Reports

                Ophthalmology & Optometry
                allogenic cornea,epikeratophakia,epikeratoplasty,intrastromal implant,record-holding


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